Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy.
Identifieur interne : 003B56 ( Main/Exploration ); précédent : 003B55; suivant : 003B57Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy.
Auteurs : Antonella Sistigu [Italie] ; Takahiro Yamazaki [France] ; Erika Vacchelli [France] ; Kariman Chaba [France] ; David P. Enot [France] ; Julien Adam [France] ; Ilio Vitale [Italie] ; Aicha Goubar [France] ; Elisa E. Baracco [France] ; Catarina Remédios [France] ; Laetitia Fend [France] ; Dalil Hannani [France] ; Laetitia Aymeric [France] ; Yuting Ma [France] ; Mireia Niso-Santano [France] ; Oliver Kepp [France] ; Joachim L. Schultze [Allemagne] ; Thomas Tüting [Allemagne] ; Filippo Belardelli [Italie] ; Laura Bracci [Italie] ; Valentina La Sorsa [Italie] ; Giovanna Ziccheddu [Italie] ; Paola Sestili [Italie] ; Francesca Urbani [Italie] ; Mauro Delorenzi [Suisse] ; Magali Lacroix-Triki [France] ; Virginie Quidville [France] ; Rosa Conforti [France] ; Jean-Philippe Spano [France] ; Lajos Pusztai [États-Unis] ; Vichnou Poirier-Colame [France] ; Suzette Delaloge [France] ; Frederique Penault-Llorca [France] ; Sylvain Ladoire [France] ; Laurent Arnould [France] ; Joanna Cyrta [France] ; Marie-Charlotte Dessoliers [France] ; Alexander Eggermont [France] ; Marco E. Bianchi [Italie] ; Mikael Pittet [États-Unis] ; Camilla Engblom [États-Unis] ; Christina Pfirschke [États-Unis] ; Xavier Préville [France] ; Gilles Uzè [France] ; Robert D. Schreiber [États-Unis] ; Melvyn T. Chow [Australie] ; Mark J. Smyth [Australie] ; Enrico Proietti [Italie] ; Fabrice André [France] ; Guido Kroemer [France] ; Laurence Zitvogel [France]Source :
- Nature medicine [ 1546-170X ] ; 2014.
Descripteurs français
- KwdFr :
- ARN (métabolisme), ARN messager (génétique), ARN messager (métabolisme), Animaux, Anthracyclines (pharmacologie), Anthracyclines (usage thérapeutique), Chimiokine CXCL10 (métabolisme), Doxorubicine (pharmacologie), Doxorubicine (usage thérapeutique), Femelle, Humains, Immunocompétence (), Interféron de type I (biosynthèse), Interféron de type I (métabolisme), Métastase tumorale, Protéines adaptatrices du transport vésiculaire (métabolisme), Protéines de résistance aux myxovirus (métabolisme), Récepteur de type Toll-3 (métabolisme), Récepteur à l'interféron alpha-bêta (métabolisme), Récepteurs de reconnaissance de motifs moléculaires (métabolisme), Régulation de l'expression des gènes tumoraux (), Résultat thérapeutique, Souris de lignée C57BL, Traitement néoadjuvant, Transduction du signal (), Tumeurs du sein (anatomopathologie), Tumeurs du sein (génétique), Tumeurs du sein (immunologie), Tumeurs du sein (traitement médicamenteux).
- MESH :
- anatomopathologie : Tumeurs du sein.
- biosynthèse : Interféron de type I.
- génétique : ARN messager, Tumeurs du sein.
- immunologie : Tumeurs du sein.
- métabolisme : ARN, ARN messager, Chimiokine CXCL10, Interféron de type I, Protéines adaptatrices du transport vésiculaire, Protéines de résistance aux myxovirus, Récepteur de type Toll-3, Récepteur à l'interféron alpha-bêta, Récepteurs de reconnaissance de motifs moléculaires.
- pharmacologie : Anthracyclines, Doxorubicine.
- traitement médicamenteux : Tumeurs du sein.
- usage thérapeutique : Anthracyclines, Doxorubicine.
- Animaux, Femelle, Humains, Immunocompétence, Métastase tumorale, Régulation de l'expression des gènes tumoraux, Résultat thérapeutique, Souris de lignée C57BL, Traitement néoadjuvant, Transduction du signal.
English descriptors
- KwdEn :
- Adaptor Proteins, Vesicular Transport (metabolism), Animals, Anthracyclines (pharmacology), Anthracyclines (therapeutic use), Breast Neoplasms (drug therapy), Breast Neoplasms (genetics), Breast Neoplasms (immunology), Breast Neoplasms (pathology), Chemokine CXCL10 (metabolism), Doxorubicin (pharmacology), Doxorubicin (therapeutic use), Female, Gene Expression Regulation, Neoplastic (drug effects), Humans, Immunocompetence (drug effects), Interferon Type I (biosynthesis), Interferon Type I (metabolism), Mice, Inbred C57BL, Myxovirus Resistance Proteins (metabolism), Neoadjuvant Therapy, Neoplasm Metastasis, RNA (metabolism), RNA, Messenger (genetics), RNA, Messenger (metabolism), Receptor, Interferon alpha-beta (metabolism), Receptors, Pattern Recognition (metabolism), Signal Transduction (drug effects), Toll-Like Receptor 3 (metabolism), Treatment Outcome.
- MESH :
- chemical , biosynthesis : Interferon Type I.
- chemical , genetics : RNA, Messenger.
- chemical , metabolism : Adaptor Proteins, Vesicular Transport, Chemokine CXCL10, Interferon Type I, Myxovirus Resistance Proteins, RNA, RNA, Messenger, Receptor, Interferon alpha-beta, Receptors, Pattern Recognition, Toll-Like Receptor 3.
- chemical , pharmacology : Anthracyclines, Doxorubicin.
- chemical , therapeutic use : Anthracyclines, Doxorubicin.
- drug effects : Gene Expression Regulation, Neoplastic, Immunocompetence, Signal Transduction.
- drug therapy : Breast Neoplasms.
- genetics : Breast Neoplasms.
- immunology : Breast Neoplasms.
- pathology : Breast Neoplasms.
- Animals, Female, Humans, Mice, Inbred C57BL, Neoadjuvant Therapy, Neoplasm Metastasis, Treatment Outcome.
Abstract
Some of the anti-neoplastic effects of anthracyclines in mice originate from the induction of innate and T cell-mediated anticancer immune responses. Here we demonstrate that anthracyclines stimulate the rapid production of type I interferons (IFNs) by malignant cells after activation of the endosomal pattern recognition receptor Toll-like receptor 3 (TLR3). By binding to IFN-α and IFN-β receptors (IFNARs) on neoplastic cells, type I IFNs trigger autocrine and paracrine circuitries that result in the release of chemokine (C-X-C motif) ligand 10 (CXCL10). Tumors lacking Tlr3 or Ifnar failed to respond to chemotherapy unless type I IFN or Cxcl10, respectively, was artificially supplied. Moreover, a type I IFN-related signature predicted clinical responses to anthracycline-based chemotherapy in several independent cohorts of patients with breast carcinoma characterized by poor prognosis. Our data suggest that anthracycline-mediated immune responses mimic those induced by viral pathogens. We surmise that such 'viral mimicry' constitutes a hallmark of successful chemotherapy.
DOI: 10.1038/nm.3708
PubMed: 25344738
Affiliations:
- Allemagne, Australie, France, Italie, Suisse, États-Unis
- Auvergne (région administrative), Auvergne-Rhône-Alpes, Bourgogne, Bourgogne-Franche-Comté, Canton de Vaud, Connecticut, District de Cologne, Languedoc-Roussillon, Latium, Lombardie, Massachusetts, Midi-Pyrénées, Missouri (État), Occitanie (région administrative), Rhénanie-du-Nord-Westphalie, Île-de-France
- Bonn, Clermont-Ferrand, Dijon, Lausanne, Milan, Montpellier, Paris, Rome, Saint-Louis (Missouri), Toulouse
- Université Paris-Descartes, École de médecine (Université Washington de Saint-Louis)
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Le document en format XML
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[4] Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Yamazaki, Takahiro" sort="Yamazaki, Takahiro" uniqKey="Yamazaki T" first="Takahiro" last="Yamazaki">Takahiro Yamazaki</name><affiliation wicri:level="1"><nlm:affiliation>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] INSERM, U1015, Villejuif, France. [3] Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] INSERM, U1015, Villejuif, France. [3] Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Vacchelli, Erika" sort="Vacchelli, Erika" uniqKey="Vacchelli E" first="Erika" last="Vacchelli">Erika Vacchelli</name><affiliation wicri:level="1"><nlm:affiliation>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre, France. [3] INSERM, U848, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre, France. [3] INSERM, U848, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Chaba, Kariman" sort="Chaba, Kariman" uniqKey="Chaba K" first="Kariman" last="Chaba">Kariman Chaba</name><affiliation wicri:level="4"><nlm:affiliation>1] INSERM, U848, Villejuif, France. [2] Equipe 11 Labellisée par la Ligue Nationale Contre le Cancer, Centre de Recherche des Cordeliers, Paris, France. [3] Université Paris Descartes, Sorbonne Paris Cité, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] INSERM, U848, Villejuif, France. [2] Equipe 11 Labellisée par la Ligue Nationale Contre le Cancer, Centre de Recherche des Cordeliers, Paris, France. [3] Université Paris Descartes, Sorbonne Paris Cité, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation></author><author><name sortKey="Enot, David P" sort="Enot, David P" uniqKey="Enot D" first="David P" last="Enot">David P. Enot</name><affiliation wicri:level="4"><nlm:affiliation>1] INSERM, U848, Villejuif, France. [2] Equipe 11 Labellisée par la Ligue Nationale Contre le Cancer, Centre de Recherche des Cordeliers, Paris, France. [3] Université Paris Descartes, Sorbonne Paris Cité, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] INSERM, U848, Villejuif, France. [2] Equipe 11 Labellisée par la Ligue Nationale Contre le Cancer, Centre de Recherche des Cordeliers, Paris, France. [3] Université Paris Descartes, Sorbonne Paris Cité, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation></author><author><name sortKey="Adam, Julien" sort="Adam, Julien" uniqKey="Adam J" first="Julien" last="Adam">Julien Adam</name><affiliation wicri:level="1"><nlm:affiliation>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] Department of Biology and Pathology, Gustave Roussy Cancer Campus, Villejuif, France. [3] Department of Medical Oncology, Gustave Roussy Cancer Campus, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] Department of Biology and Pathology, Gustave Roussy Cancer Campus, Villejuif, France. [3] Department of Medical Oncology, Gustave Roussy Cancer Campus, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Vitale, Ilio" sort="Vitale, Ilio" uniqKey="Vitale I" first="Ilio" last="Vitale">Ilio Vitale</name><affiliation wicri:level="3"><nlm:affiliation>Regina Elena National Cancer Institute, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Regina Elena National Cancer Institute, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Goubar, Aicha" sort="Goubar, Aicha" uniqKey="Goubar A" first="Aicha" last="Goubar">Aicha Goubar</name><affiliation wicri:level="1"><nlm:affiliation>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] INSERM, U981, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] INSERM, U981, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Baracco, Elisa E" sort="Baracco, Elisa E" uniqKey="Baracco E" first="Elisa E" last="Baracco">Elisa E. Baracco</name><affiliation wicri:level="1"><nlm:affiliation>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre, France. [3] INSERM, U848, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre, France. [3] INSERM, U848, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Remedios, Catarina" sort="Remedios, Catarina" uniqKey="Remedios C" first="Catarina" last="Remédios">Catarina Remédios</name><affiliation wicri:level="1"><nlm:affiliation>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] INSERM, U1015, Villejuif, France. [3] Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] INSERM, U1015, Villejuif, France. [3] Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Fend, Laetitia" sort="Fend, Laetitia" uniqKey="Fend L" first="Laetitia" last="Fend">Laetitia Fend</name><affiliation wicri:level="1"><nlm:affiliation>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] INSERM, U1015, Villejuif, France. [3] Transgene S.A., Illkirch-Graffenstaden, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] INSERM, U1015, Villejuif, France. [3] Transgene S.A., Illkirch-Graffenstaden</wicri:regionArea><wicri:noRegion>Illkirch-Graffenstaden</wicri:noRegion><wicri:noRegion>Illkirch-Graffenstaden</wicri:noRegion></affiliation></author><author><name sortKey="Hannani, Dalil" sort="Hannani, Dalil" uniqKey="Hannani D" first="Dalil" last="Hannani">Dalil Hannani</name><affiliation wicri:level="1"><nlm:affiliation>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] INSERM, U1015, Villejuif, France. [3] Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] INSERM, U1015, Villejuif, France. [3] Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Aymeric, Laetitia" sort="Aymeric, Laetitia" uniqKey="Aymeric L" first="Laetitia" last="Aymeric">Laetitia Aymeric</name><affiliation wicri:level="1"><nlm:affiliation>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] INSERM, U1015, Villejuif, France. [3] Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] INSERM, U1015, Villejuif, France. [3] Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Ma, Yuting" sort="Ma, Yuting" uniqKey="Ma Y" first="Yuting" last="Ma">Yuting Ma</name><affiliation wicri:level="1"><nlm:affiliation>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre, France. [3] INSERM, U848, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre, France. [3] INSERM, U848, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Niso Santano, Mireia" sort="Niso Santano, Mireia" uniqKey="Niso Santano M" first="Mireia" last="Niso-Santano">Mireia Niso-Santano</name><affiliation wicri:level="1"><nlm:affiliation>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre, France. [3] INSERM, U848, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre, France. [3] INSERM, U848, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Kepp, Oliver" sort="Kepp, Oliver" uniqKey="Kepp O" first="Oliver" last="Kepp">Oliver Kepp</name><affiliation wicri:level="1"><nlm:affiliation>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre, France. [3] INSERM, U848, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre, France. [3] INSERM, U848, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Schultze, Joachim L" sort="Schultze, Joachim L" uniqKey="Schultze J" first="Joachim L" last="Schultze">Joachim L. Schultze</name><affiliation wicri:level="3"><nlm:affiliation>Laboratory for Genomics and Immunoregulation, Life and Medical Sciences (LIMES), University of Bonn, Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Laboratory for Genomics and Immunoregulation, Life and Medical Sciences (LIMES), University of Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Tuting, Thomas" sort="Tuting, Thomas" uniqKey="Tuting T" first="Thomas" last="Tüting">Thomas Tüting</name><affiliation wicri:level="3"><nlm:affiliation>Laboratory of Experimental Dermatology, Department of Dermatology, University Hospital Bonn, Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Laboratory of Experimental Dermatology, Department of Dermatology, University Hospital Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Belardelli, Filippo" sort="Belardelli, Filippo" uniqKey="Belardelli F" first="Filippo" last="Belardelli">Filippo Belardelli</name><affiliation wicri:level="3"><nlm:affiliation>Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Bracci, Laura" sort="Bracci, Laura" uniqKey="Bracci L" first="Laura" last="Bracci">Laura Bracci</name><affiliation wicri:level="3"><nlm:affiliation>Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="La Sorsa, Valentina" sort="La Sorsa, Valentina" uniqKey="La Sorsa V" first="Valentina" last="La Sorsa">Valentina La Sorsa</name><affiliation wicri:level="3"><nlm:affiliation>Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Ziccheddu, Giovanna" sort="Ziccheddu, Giovanna" uniqKey="Ziccheddu G" first="Giovanna" last="Ziccheddu">Giovanna Ziccheddu</name><affiliation wicri:level="3"><nlm:affiliation>Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Sestili, Paola" sort="Sestili, Paola" uniqKey="Sestili P" first="Paola" last="Sestili">Paola Sestili</name><affiliation wicri:level="3"><nlm:affiliation>Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Urbani, Francesca" sort="Urbani, Francesca" uniqKey="Urbani F" first="Francesca" last="Urbani">Francesca Urbani</name><affiliation wicri:level="3"><nlm:affiliation>Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Delorenzi, Mauro" sort="Delorenzi, Mauro" uniqKey="Delorenzi M" first="Mauro" last="Delorenzi">Mauro Delorenzi</name><affiliation wicri:level="3"><nlm:affiliation>1] SIB-Swiss Institute of Bioinformatics, Lausanne, Switzerland. [2] National Center of Competence in Research (NCCR) Molecular Oncology, Institut Suisse de Recherche Expérimentale sur le Cancer (ISREC), School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. [3] Departement de Formation et Recherche, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>1] SIB-Swiss Institute of Bioinformatics, Lausanne, Switzerland. [2] National Center of Competence in Research (NCCR) Molecular Oncology, Institut Suisse de Recherche Expérimentale sur le Cancer (ISREC), School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. [3] Departement de Formation et Recherche, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Lacroix Triki, Magali" sort="Lacroix Triki, Magali" uniqKey="Lacroix Triki M" first="Magali" last="Lacroix-Triki">Magali Lacroix-Triki</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, Centre Claudius Regaud, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Pathology, Centre Claudius Regaud, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Quidville, Virginie" sort="Quidville, Virginie" uniqKey="Quidville V" first="Virginie" last="Quidville">Virginie Quidville</name><affiliation wicri:level="1"><nlm:affiliation>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] Department of Medical Oncology, Gustave Roussy Cancer Campus, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] Department of Medical Oncology, Gustave Roussy Cancer Campus, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Conforti, Rosa" sort="Conforti, Rosa" uniqKey="Conforti R" first="Rosa" last="Conforti">Rosa Conforti</name><affiliation wicri:level="3"><nlm:affiliation>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] INSERM, U1015, Villejuif, France. [3] Center of Clinical Investigations in Biotherapies of Cancer (CICBT) 507, Villejuif, France. [4] Department of Medical Oncology, Hôpital Pitie Salpetriere, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] INSERM, U1015, Villejuif, France. [3] Center of Clinical Investigations in Biotherapies of Cancer (CICBT) 507, Villejuif, France. [4] Department of Medical Oncology, Hôpital Pitie Salpetriere, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Spano, Jean Philippe" sort="Spano, Jean Philippe" uniqKey="Spano J" first="Jean-Philippe" last="Spano">Jean-Philippe Spano</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, Hôpital Pitie Salpetriere, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Medical Oncology, Hôpital Pitie Salpetriere, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Pusztai, Lajos" sort="Pusztai, Lajos" uniqKey="Pusztai L" first="Lajos" last="Pusztai">Lajos Pusztai</name><affiliation wicri:level="2"><nlm:affiliation>Yale School of Medicine, New Haven, Connecticut, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Yale School of Medicine, New Haven, Connecticut</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Poirier Colame, Vichnou" sort="Poirier Colame, Vichnou" uniqKey="Poirier Colame V" first="Vichnou" last="Poirier-Colame">Vichnou Poirier-Colame</name><affiliation wicri:level="1"><nlm:affiliation>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] INSERM, U1015, Villejuif, France. [3] Center of Clinical Investigations in Biotherapies of Cancer (CICBT) 507, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] INSERM, U1015, Villejuif, France. [3] Center of Clinical Investigations in Biotherapies of Cancer (CICBT) 507, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Delaloge, Suzette" sort="Delaloge, Suzette" uniqKey="Delaloge S" first="Suzette" last="Delaloge">Suzette Delaloge</name><affiliation wicri:level="1"><nlm:affiliation>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] Department of Biology and Pathology, Gustave Roussy Cancer Campus, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] Department of Biology and Pathology, Gustave Roussy Cancer Campus, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Penault Llorca, Frederique" sort="Penault Llorca, Frederique" uniqKey="Penault Llorca F" first="Frederique" last="Penault-Llorca">Frederique Penault-Llorca</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, Jean Perrin Center, EA 4677 ERTICa, University of Auvergne, Clermont-Ferrand, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Pathology, Jean Perrin Center, EA 4677 ERTICa, University of Auvergne, Clermont-Ferrand</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Ladoire, Sylvain" sort="Ladoire, Sylvain" uniqKey="Ladoire S" first="Sylvain" last="Ladoire">Sylvain Ladoire</name><affiliation wicri:level="3"><nlm:affiliation>1] Department of Medical Oncology, Centre Georges-François Leclerc, Dijon, France. [2] INSERM, CRI-866 Faculty of Medicine, Dijon, France. [3] University of Burgundy, Dijon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Department of Medical Oncology, Centre Georges-François Leclerc, Dijon, France. [2] INSERM, CRI-866 Faculty of Medicine, Dijon, France. [3] University of Burgundy, Dijon</wicri:regionArea><placeName><region type="region">Bourgogne-Franche-Comté</region><region type="old region">Bourgogne</region><settlement type="city">Dijon</settlement></placeName></affiliation></author><author><name sortKey="Arnould, Laurent" sort="Arnould, Laurent" uniqKey="Arnould L" first="Laurent" last="Arnould">Laurent Arnould</name><affiliation wicri:level="3"><nlm:affiliation>1] Department of Medical Oncology, Centre Georges-François Leclerc, Dijon, France. [2] INSERM, CRI-866 Faculty of Medicine, Dijon, France. [3] University of Burgundy, Dijon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Department of Medical Oncology, Centre Georges-François Leclerc, Dijon, France. [2] INSERM, CRI-866 Faculty of Medicine, Dijon, France. [3] University of Burgundy, Dijon</wicri:regionArea><placeName><region type="region">Bourgogne-Franche-Comté</region><region type="old region">Bourgogne</region><settlement type="city">Dijon</settlement></placeName></affiliation></author><author><name sortKey="Cyrta, Joanna" sort="Cyrta, Joanna" uniqKey="Cyrta J" first="Joanna" last="Cyrta">Joanna Cyrta</name><affiliation wicri:level="1"><nlm:affiliation>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] Department of Biology and Pathology, Gustave Roussy Cancer Campus, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] Department of Biology and Pathology, Gustave Roussy Cancer Campus, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Dessoliers, Marie Charlotte" sort="Dessoliers, Marie Charlotte" uniqKey="Dessoliers M" first="Marie-Charlotte" last="Dessoliers">Marie-Charlotte Dessoliers</name><affiliation wicri:level="1"><nlm:affiliation>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] INSERM, U981, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] INSERM, U981, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Eggermont, Alexander" sort="Eggermont, Alexander" uniqKey="Eggermont A" first="Alexander" last="Eggermont">Alexander Eggermont</name><affiliation wicri:level="1"><nlm:affiliation>Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Bianchi, Marco E" sort="Bianchi, Marco E" uniqKey="Bianchi M" first="Marco E" last="Bianchi">Marco E. Bianchi</name><affiliation wicri:level="3"><nlm:affiliation>San Raffaele University and Scientific Institute, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>San Raffaele University and Scientific Institute, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Pittet, Mikael" sort="Pittet, Mikael" uniqKey="Pittet M" first="Mikael" last="Pittet">Mikael Pittet</name><affiliation wicri:level="2"><nlm:affiliation>1] Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, USA. [2] Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, USA. [2] Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Engblom, Camilla" sort="Engblom, Camilla" uniqKey="Engblom C" first="Camilla" last="Engblom">Camilla Engblom</name><affiliation wicri:level="2"><nlm:affiliation>1] Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, USA. [2] Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, USA. [2] Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Pfirschke, Christina" sort="Pfirschke, Christina" uniqKey="Pfirschke C" first="Christina" last="Pfirschke">Christina Pfirschke</name><affiliation wicri:level="2"><nlm:affiliation>1] Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, USA. [2] Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, USA. [2] Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Preville, Xavier" sort="Preville, Xavier" uniqKey="Preville X" first="Xavier" last="Préville">Xavier Préville</name><affiliation wicri:level="1"><nlm:affiliation>Transgene S.A., Illkirch-Graffenstaden, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Transgene S.A., Illkirch-Graffenstaden</wicri:regionArea><wicri:noRegion>Illkirch-Graffenstaden</wicri:noRegion><wicri:noRegion>Illkirch-Graffenstaden</wicri:noRegion></affiliation></author><author><name sortKey="Uze, Gilles" sort="Uze, Gilles" uniqKey="Uze G" first="Gilles" last="Uzè">Gilles Uzè</name><affiliation wicri:level="3"><nlm:affiliation>CNRS UMR5235, University Montpellier II, Place Eugène Bataillon, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS UMR5235, University Montpellier II, Place Eugène Bataillon, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Schreiber, Robert D" sort="Schreiber, Robert D" uniqKey="Schreiber R" first="Robert D" last="Schreiber">Robert D. Schreiber</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation></author><author><name sortKey="Chow, Melvyn T" sort="Chow, Melvyn T" uniqKey="Chow M" first="Melvyn T" last="Chow">Melvyn T. Chow</name><affiliation wicri:level="1"><nlm:affiliation>Queensland Institute of Medical Research, Herston, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Herston, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Smyth, Mark J" sort="Smyth, Mark J" uniqKey="Smyth M" first="Mark J" last="Smyth">Mark J. Smyth</name><affiliation wicri:level="1"><nlm:affiliation>1] Queensland Institute of Medical Research, Herston, Queensland, Australia. [2] School of Medicine, The University of Queensland, Herston, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>1] Queensland Institute of Medical Research, Herston, Queensland, Australia. [2] School of Medicine, The University of Queensland, Herston, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Proietti, Enrico" sort="Proietti, Enrico" uniqKey="Proietti E" first="Enrico" last="Proietti">Enrico Proietti</name><affiliation wicri:level="3"><nlm:affiliation>Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Andre, Fabrice" sort="Andre, Fabrice" uniqKey="Andre F" first="Fabrice" last="André">Fabrice André</name><affiliation wicri:level="1"><nlm:affiliation>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre, France. [3] Department of Biology and Pathology, Gustave Roussy Cancer Campus, Villejuif, France. [4] Department of Medical Oncology, Gustave Roussy Cancer Campus, Villejuif, France. [5] INSERM, U981, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre, France. [3] Department of Biology and Pathology, Gustave Roussy Cancer Campus, Villejuif, France. [4] Department of Medical Oncology, Gustave Roussy Cancer Campus, Villejuif, France. [5] INSERM, U981, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name><affiliation wicri:level="4"><nlm:affiliation>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] INSERM, U848, Villejuif, France. [3] Université Paris Descartes, Sorbonne Paris Cité, Paris, France. [4] Metabolomics Platform, Gustave Roussy Cancer Campus, Villejuif, France. [5] Pôle de Biologie, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] INSERM, U848, Villejuif, France. [3] Université Paris Descartes, Sorbonne Paris Cité, Paris, France. [4] Metabolomics Platform, Gustave Roussy Cancer Campus, Villejuif, France. [5] Pôle de Biologie, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation></author><author><name sortKey="Zitvogel, Laurence" sort="Zitvogel, Laurence" uniqKey="Zitvogel L" first="Laurence" last="Zitvogel">Laurence Zitvogel</name><affiliation wicri:level="1"><nlm:affiliation>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre, France. [3] Center of Clinical Investigations in Biotherapies of Cancer (CICBT) 507, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre, France. [3] Center of Clinical Investigations in Biotherapies of Cancer (CICBT) 507, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:25344738</idno><idno type="pmid">25344738</idno><idno type="doi">10.1038/nm.3708</idno><idno type="wicri:Area/PubMed/Corpus">003287</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003287</idno><idno type="wicri:Area/PubMed/Curation">003177</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003177</idno><idno type="wicri:Area/PubMed/Checkpoint">003177</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003177</idno><idno type="wicri:Area/Ncbi/Merge">001F39</idno><idno type="wicri:Area/Ncbi/Curation">001F39</idno><idno type="wicri:Area/Ncbi/Checkpoint">001F39</idno><idno type="wicri:Area/Main/Merge">003C04</idno><idno type="wicri:Area/Main/Curation">003B56</idno><idno type="wicri:Area/Main/Exploration">003B56</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy.</title><author><name sortKey="Sistigu, Antonella" sort="Sistigu, Antonella" uniqKey="Sistigu A" first="Antonella" last="Sistigu">Antonella Sistigu</name><affiliation wicri:level="3"><nlm:affiliation>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] INSERM, U1015, Villejuif, France. [3] Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre, France. [4] Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] INSERM, U1015, Villejuif, France. [3] Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre, France. [4] Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Yamazaki, Takahiro" sort="Yamazaki, Takahiro" uniqKey="Yamazaki T" first="Takahiro" last="Yamazaki">Takahiro Yamazaki</name><affiliation wicri:level="1"><nlm:affiliation>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] INSERM, U1015, Villejuif, France. [3] Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] INSERM, U1015, Villejuif, France. [3] Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Vacchelli, Erika" sort="Vacchelli, Erika" uniqKey="Vacchelli E" first="Erika" last="Vacchelli">Erika Vacchelli</name><affiliation wicri:level="1"><nlm:affiliation>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre, France. [3] INSERM, U848, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre, France. [3] INSERM, U848, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Chaba, Kariman" sort="Chaba, Kariman" uniqKey="Chaba K" first="Kariman" last="Chaba">Kariman Chaba</name><affiliation wicri:level="4"><nlm:affiliation>1] INSERM, U848, Villejuif, France. [2] Equipe 11 Labellisée par la Ligue Nationale Contre le Cancer, Centre de Recherche des Cordeliers, Paris, France. [3] Université Paris Descartes, Sorbonne Paris Cité, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] INSERM, U848, Villejuif, France. [2] Equipe 11 Labellisée par la Ligue Nationale Contre le Cancer, Centre de Recherche des Cordeliers, Paris, France. [3] Université Paris Descartes, Sorbonne Paris Cité, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation></author><author><name sortKey="Enot, David P" sort="Enot, David P" uniqKey="Enot D" first="David P" last="Enot">David P. Enot</name><affiliation wicri:level="4"><nlm:affiliation>1] INSERM, U848, Villejuif, France. [2] Equipe 11 Labellisée par la Ligue Nationale Contre le Cancer, Centre de Recherche des Cordeliers, Paris, France. [3] Université Paris Descartes, Sorbonne Paris Cité, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] INSERM, U848, Villejuif, France. [2] Equipe 11 Labellisée par la Ligue Nationale Contre le Cancer, Centre de Recherche des Cordeliers, Paris, France. [3] Université Paris Descartes, Sorbonne Paris Cité, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation></author><author><name sortKey="Adam, Julien" sort="Adam, Julien" uniqKey="Adam J" first="Julien" last="Adam">Julien Adam</name><affiliation wicri:level="1"><nlm:affiliation>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] Department of Biology and Pathology, Gustave Roussy Cancer Campus, Villejuif, France. [3] Department of Medical Oncology, Gustave Roussy Cancer Campus, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] Department of Biology and Pathology, Gustave Roussy Cancer Campus, Villejuif, France. [3] Department of Medical Oncology, Gustave Roussy Cancer Campus, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Vitale, Ilio" sort="Vitale, Ilio" uniqKey="Vitale I" first="Ilio" last="Vitale">Ilio Vitale</name><affiliation wicri:level="3"><nlm:affiliation>Regina Elena National Cancer Institute, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Regina Elena National Cancer Institute, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Goubar, Aicha" sort="Goubar, Aicha" uniqKey="Goubar A" first="Aicha" last="Goubar">Aicha Goubar</name><affiliation wicri:level="1"><nlm:affiliation>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] INSERM, U981, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] INSERM, U981, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Baracco, Elisa E" sort="Baracco, Elisa E" uniqKey="Baracco E" first="Elisa E" last="Baracco">Elisa E. Baracco</name><affiliation wicri:level="1"><nlm:affiliation>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre, France. [3] INSERM, U848, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre, France. [3] INSERM, U848, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Remedios, Catarina" sort="Remedios, Catarina" uniqKey="Remedios C" first="Catarina" last="Remédios">Catarina Remédios</name><affiliation wicri:level="1"><nlm:affiliation>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] INSERM, U1015, Villejuif, France. [3] Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] INSERM, U1015, Villejuif, France. [3] Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Fend, Laetitia" sort="Fend, Laetitia" uniqKey="Fend L" first="Laetitia" last="Fend">Laetitia Fend</name><affiliation wicri:level="1"><nlm:affiliation>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] INSERM, U1015, Villejuif, France. [3] Transgene S.A., Illkirch-Graffenstaden, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] INSERM, U1015, Villejuif, France. [3] Transgene S.A., Illkirch-Graffenstaden</wicri:regionArea><wicri:noRegion>Illkirch-Graffenstaden</wicri:noRegion><wicri:noRegion>Illkirch-Graffenstaden</wicri:noRegion></affiliation></author><author><name sortKey="Hannani, Dalil" sort="Hannani, Dalil" uniqKey="Hannani D" first="Dalil" last="Hannani">Dalil Hannani</name><affiliation wicri:level="1"><nlm:affiliation>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] INSERM, U1015, Villejuif, France. [3] Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] INSERM, U1015, Villejuif, France. [3] Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Aymeric, Laetitia" sort="Aymeric, Laetitia" uniqKey="Aymeric L" first="Laetitia" last="Aymeric">Laetitia Aymeric</name><affiliation wicri:level="1"><nlm:affiliation>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] INSERM, U1015, Villejuif, France. [3] Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] INSERM, U1015, Villejuif, France. [3] Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Ma, Yuting" sort="Ma, Yuting" uniqKey="Ma Y" first="Yuting" last="Ma">Yuting Ma</name><affiliation wicri:level="1"><nlm:affiliation>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre, France. [3] INSERM, U848, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre, France. [3] INSERM, U848, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Niso Santano, Mireia" sort="Niso Santano, Mireia" uniqKey="Niso Santano M" first="Mireia" last="Niso-Santano">Mireia Niso-Santano</name><affiliation wicri:level="1"><nlm:affiliation>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre, France. [3] INSERM, U848, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre, France. [3] INSERM, U848, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Kepp, Oliver" sort="Kepp, Oliver" uniqKey="Kepp O" first="Oliver" last="Kepp">Oliver Kepp</name><affiliation wicri:level="1"><nlm:affiliation>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre, France. [3] INSERM, U848, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre, France. [3] INSERM, U848, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Schultze, Joachim L" sort="Schultze, Joachim L" uniqKey="Schultze J" first="Joachim L" last="Schultze">Joachim L. Schultze</name><affiliation wicri:level="3"><nlm:affiliation>Laboratory for Genomics and Immunoregulation, Life and Medical Sciences (LIMES), University of Bonn, Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Laboratory for Genomics and Immunoregulation, Life and Medical Sciences (LIMES), University of Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Tuting, Thomas" sort="Tuting, Thomas" uniqKey="Tuting T" first="Thomas" last="Tüting">Thomas Tüting</name><affiliation wicri:level="3"><nlm:affiliation>Laboratory of Experimental Dermatology, Department of Dermatology, University Hospital Bonn, Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Laboratory of Experimental Dermatology, Department of Dermatology, University Hospital Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Belardelli, Filippo" sort="Belardelli, Filippo" uniqKey="Belardelli F" first="Filippo" last="Belardelli">Filippo Belardelli</name><affiliation wicri:level="3"><nlm:affiliation>Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Bracci, Laura" sort="Bracci, Laura" uniqKey="Bracci L" first="Laura" last="Bracci">Laura Bracci</name><affiliation wicri:level="3"><nlm:affiliation>Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="La Sorsa, Valentina" sort="La Sorsa, Valentina" uniqKey="La Sorsa V" first="Valentina" last="La Sorsa">Valentina La Sorsa</name><affiliation wicri:level="3"><nlm:affiliation>Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Ziccheddu, Giovanna" sort="Ziccheddu, Giovanna" uniqKey="Ziccheddu G" first="Giovanna" last="Ziccheddu">Giovanna Ziccheddu</name><affiliation wicri:level="3"><nlm:affiliation>Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Sestili, Paola" sort="Sestili, Paola" uniqKey="Sestili P" first="Paola" last="Sestili">Paola Sestili</name><affiliation wicri:level="3"><nlm:affiliation>Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Urbani, Francesca" sort="Urbani, Francesca" uniqKey="Urbani F" first="Francesca" last="Urbani">Francesca Urbani</name><affiliation wicri:level="3"><nlm:affiliation>Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Delorenzi, Mauro" sort="Delorenzi, Mauro" uniqKey="Delorenzi M" first="Mauro" last="Delorenzi">Mauro Delorenzi</name><affiliation wicri:level="3"><nlm:affiliation>1] SIB-Swiss Institute of Bioinformatics, Lausanne, Switzerland. [2] National Center of Competence in Research (NCCR) Molecular Oncology, Institut Suisse de Recherche Expérimentale sur le Cancer (ISREC), School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. [3] Departement de Formation et Recherche, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>1] SIB-Swiss Institute of Bioinformatics, Lausanne, Switzerland. [2] National Center of Competence in Research (NCCR) Molecular Oncology, Institut Suisse de Recherche Expérimentale sur le Cancer (ISREC), School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. [3] Departement de Formation et Recherche, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Lacroix Triki, Magali" sort="Lacroix Triki, Magali" uniqKey="Lacroix Triki M" first="Magali" last="Lacroix-Triki">Magali Lacroix-Triki</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, Centre Claudius Regaud, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Pathology, Centre Claudius Regaud, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Quidville, Virginie" sort="Quidville, Virginie" uniqKey="Quidville V" first="Virginie" last="Quidville">Virginie Quidville</name><affiliation wicri:level="1"><nlm:affiliation>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] Department of Medical Oncology, Gustave Roussy Cancer Campus, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] Department of Medical Oncology, Gustave Roussy Cancer Campus, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Conforti, Rosa" sort="Conforti, Rosa" uniqKey="Conforti R" first="Rosa" last="Conforti">Rosa Conforti</name><affiliation wicri:level="3"><nlm:affiliation>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] INSERM, U1015, Villejuif, France. [3] Center of Clinical Investigations in Biotherapies of Cancer (CICBT) 507, Villejuif, France. [4] Department of Medical Oncology, Hôpital Pitie Salpetriere, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] INSERM, U1015, Villejuif, France. [3] Center of Clinical Investigations in Biotherapies of Cancer (CICBT) 507, Villejuif, France. [4] Department of Medical Oncology, Hôpital Pitie Salpetriere, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Spano, Jean Philippe" sort="Spano, Jean Philippe" uniqKey="Spano J" first="Jean-Philippe" last="Spano">Jean-Philippe Spano</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, Hôpital Pitie Salpetriere, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Medical Oncology, Hôpital Pitie Salpetriere, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Pusztai, Lajos" sort="Pusztai, Lajos" uniqKey="Pusztai L" first="Lajos" last="Pusztai">Lajos Pusztai</name><affiliation wicri:level="2"><nlm:affiliation>Yale School of Medicine, New Haven, Connecticut, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Yale School of Medicine, New Haven, Connecticut</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Poirier Colame, Vichnou" sort="Poirier Colame, Vichnou" uniqKey="Poirier Colame V" first="Vichnou" last="Poirier-Colame">Vichnou Poirier-Colame</name><affiliation wicri:level="1"><nlm:affiliation>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] INSERM, U1015, Villejuif, France. [3] Center of Clinical Investigations in Biotherapies of Cancer (CICBT) 507, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] INSERM, U1015, Villejuif, France. [3] Center of Clinical Investigations in Biotherapies of Cancer (CICBT) 507, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Delaloge, Suzette" sort="Delaloge, Suzette" uniqKey="Delaloge S" first="Suzette" last="Delaloge">Suzette Delaloge</name><affiliation wicri:level="1"><nlm:affiliation>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] Department of Biology and Pathology, Gustave Roussy Cancer Campus, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] Department of Biology and Pathology, Gustave Roussy Cancer Campus, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Penault Llorca, Frederique" sort="Penault Llorca, Frederique" uniqKey="Penault Llorca F" first="Frederique" last="Penault-Llorca">Frederique Penault-Llorca</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, Jean Perrin Center, EA 4677 ERTICa, University of Auvergne, Clermont-Ferrand, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Pathology, Jean Perrin Center, EA 4677 ERTICa, University of Auvergne, Clermont-Ferrand</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Ladoire, Sylvain" sort="Ladoire, Sylvain" uniqKey="Ladoire S" first="Sylvain" last="Ladoire">Sylvain Ladoire</name><affiliation wicri:level="3"><nlm:affiliation>1] Department of Medical Oncology, Centre Georges-François Leclerc, Dijon, France. [2] INSERM, CRI-866 Faculty of Medicine, Dijon, France. [3] University of Burgundy, Dijon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Department of Medical Oncology, Centre Georges-François Leclerc, Dijon, France. [2] INSERM, CRI-866 Faculty of Medicine, Dijon, France. [3] University of Burgundy, Dijon</wicri:regionArea><placeName><region type="region">Bourgogne-Franche-Comté</region><region type="old region">Bourgogne</region><settlement type="city">Dijon</settlement></placeName></affiliation></author><author><name sortKey="Arnould, Laurent" sort="Arnould, Laurent" uniqKey="Arnould L" first="Laurent" last="Arnould">Laurent Arnould</name><affiliation wicri:level="3"><nlm:affiliation>1] Department of Medical Oncology, Centre Georges-François Leclerc, Dijon, France. [2] INSERM, CRI-866 Faculty of Medicine, Dijon, France. [3] University of Burgundy, Dijon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Department of Medical Oncology, Centre Georges-François Leclerc, Dijon, France. [2] INSERM, CRI-866 Faculty of Medicine, Dijon, France. [3] University of Burgundy, Dijon</wicri:regionArea><placeName><region type="region">Bourgogne-Franche-Comté</region><region type="old region">Bourgogne</region><settlement type="city">Dijon</settlement></placeName></affiliation></author><author><name sortKey="Cyrta, Joanna" sort="Cyrta, Joanna" uniqKey="Cyrta J" first="Joanna" last="Cyrta">Joanna Cyrta</name><affiliation wicri:level="1"><nlm:affiliation>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] Department of Biology and Pathology, Gustave Roussy Cancer Campus, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] Department of Biology and Pathology, Gustave Roussy Cancer Campus, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Dessoliers, Marie Charlotte" sort="Dessoliers, Marie Charlotte" uniqKey="Dessoliers M" first="Marie-Charlotte" last="Dessoliers">Marie-Charlotte Dessoliers</name><affiliation wicri:level="1"><nlm:affiliation>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] INSERM, U981, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] INSERM, U981, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Eggermont, Alexander" sort="Eggermont, Alexander" uniqKey="Eggermont A" first="Alexander" last="Eggermont">Alexander Eggermont</name><affiliation wicri:level="1"><nlm:affiliation>Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Bianchi, Marco E" sort="Bianchi, Marco E" uniqKey="Bianchi M" first="Marco E" last="Bianchi">Marco E. Bianchi</name><affiliation wicri:level="3"><nlm:affiliation>San Raffaele University and Scientific Institute, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>San Raffaele University and Scientific Institute, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Pittet, Mikael" sort="Pittet, Mikael" uniqKey="Pittet M" first="Mikael" last="Pittet">Mikael Pittet</name><affiliation wicri:level="2"><nlm:affiliation>1] Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, USA. [2] Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, USA. [2] Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Engblom, Camilla" sort="Engblom, Camilla" uniqKey="Engblom C" first="Camilla" last="Engblom">Camilla Engblom</name><affiliation wicri:level="2"><nlm:affiliation>1] Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, USA. [2] Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, USA. [2] Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Pfirschke, Christina" sort="Pfirschke, Christina" uniqKey="Pfirschke C" first="Christina" last="Pfirschke">Christina Pfirschke</name><affiliation wicri:level="2"><nlm:affiliation>1] Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, USA. [2] Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, USA. [2] Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Preville, Xavier" sort="Preville, Xavier" uniqKey="Preville X" first="Xavier" last="Préville">Xavier Préville</name><affiliation wicri:level="1"><nlm:affiliation>Transgene S.A., Illkirch-Graffenstaden, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Transgene S.A., Illkirch-Graffenstaden</wicri:regionArea><wicri:noRegion>Illkirch-Graffenstaden</wicri:noRegion><wicri:noRegion>Illkirch-Graffenstaden</wicri:noRegion></affiliation></author><author><name sortKey="Uze, Gilles" sort="Uze, Gilles" uniqKey="Uze G" first="Gilles" last="Uzè">Gilles Uzè</name><affiliation wicri:level="3"><nlm:affiliation>CNRS UMR5235, University Montpellier II, Place Eugène Bataillon, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS UMR5235, University Montpellier II, Place Eugène Bataillon, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Schreiber, Robert D" sort="Schreiber, Robert D" uniqKey="Schreiber R" first="Robert D" last="Schreiber">Robert D. Schreiber</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation></author><author><name sortKey="Chow, Melvyn T" sort="Chow, Melvyn T" uniqKey="Chow M" first="Melvyn T" last="Chow">Melvyn T. Chow</name><affiliation wicri:level="1"><nlm:affiliation>Queensland Institute of Medical Research, Herston, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Herston, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Smyth, Mark J" sort="Smyth, Mark J" uniqKey="Smyth M" first="Mark J" last="Smyth">Mark J. Smyth</name><affiliation wicri:level="1"><nlm:affiliation>1] Queensland Institute of Medical Research, Herston, Queensland, Australia. [2] School of Medicine, The University of Queensland, Herston, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>1] Queensland Institute of Medical Research, Herston, Queensland, Australia. [2] School of Medicine, The University of Queensland, Herston, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Proietti, Enrico" sort="Proietti, Enrico" uniqKey="Proietti E" first="Enrico" last="Proietti">Enrico Proietti</name><affiliation wicri:level="3"><nlm:affiliation>Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Andre, Fabrice" sort="Andre, Fabrice" uniqKey="Andre F" first="Fabrice" last="André">Fabrice André</name><affiliation wicri:level="1"><nlm:affiliation>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre, France. [3] Department of Biology and Pathology, Gustave Roussy Cancer Campus, Villejuif, France. [4] Department of Medical Oncology, Gustave Roussy Cancer Campus, Villejuif, France. [5] INSERM, U981, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre, France. [3] Department of Biology and Pathology, Gustave Roussy Cancer Campus, Villejuif, France. [4] Department of Medical Oncology, Gustave Roussy Cancer Campus, Villejuif, France. [5] INSERM, U981, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name><affiliation wicri:level="4"><nlm:affiliation>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] INSERM, U848, Villejuif, France. [3] Université Paris Descartes, Sorbonne Paris Cité, Paris, France. [4] Metabolomics Platform, Gustave Roussy Cancer Campus, Villejuif, France. [5] Pôle de Biologie, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] INSERM, U848, Villejuif, France. [3] Université Paris Descartes, Sorbonne Paris Cité, Paris, France. [4] Metabolomics Platform, Gustave Roussy Cancer Campus, Villejuif, France. [5] Pôle de Biologie, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation></author><author><name sortKey="Zitvogel, Laurence" sort="Zitvogel, Laurence" uniqKey="Zitvogel L" first="Laurence" last="Zitvogel">Laurence Zitvogel</name><affiliation wicri:level="1"><nlm:affiliation>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre, France. [3] Center of Clinical Investigations in Biotherapies of Cancer (CICBT) 507, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Gustave Roussy Cancer Campus, Villejuif, France. [2] Université Paris Saclay, Faculté de Médecine, Le Kremlin Bicêtre, France. [3] Center of Clinical Investigations in Biotherapies of Cancer (CICBT) 507, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author></analytic><series><title level="j">Nature medicine</title><idno type="eISSN">1546-170X</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adaptor Proteins, Vesicular Transport (metabolism)</term><term>Animals</term><term>Anthracyclines (pharmacology)</term><term>Anthracyclines (therapeutic use)</term><term>Breast Neoplasms (drug therapy)</term><term>Breast Neoplasms (genetics)</term><term>Breast Neoplasms (immunology)</term><term>Breast Neoplasms (pathology)</term><term>Chemokine CXCL10 (metabolism)</term><term>Doxorubicin (pharmacology)</term><term>Doxorubicin (therapeutic use)</term><term>Female</term><term>Gene Expression Regulation, Neoplastic (drug effects)</term><term>Humans</term><term>Immunocompetence (drug effects)</term><term>Interferon Type I (biosynthesis)</term><term>Interferon Type I (metabolism)</term><term>Mice, Inbred C57BL</term><term>Myxovirus Resistance Proteins (metabolism)</term><term>Neoadjuvant Therapy</term><term>Neoplasm Metastasis</term><term>RNA (metabolism)</term><term>RNA, Messenger (genetics)</term><term>RNA, Messenger (metabolism)</term><term>Receptor, Interferon alpha-beta (metabolism)</term><term>Receptors, Pattern Recognition (metabolism)</term><term>Signal Transduction (drug effects)</term><term>Toll-Like Receptor 3 (metabolism)</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN (métabolisme)</term><term>ARN messager (génétique)</term><term>ARN messager (métabolisme)</term><term>Animaux</term><term>Anthracyclines (pharmacologie)</term><term>Anthracyclines (usage thérapeutique)</term><term>Chimiokine CXCL10 (métabolisme)</term><term>Doxorubicine (pharmacologie)</term><term>Doxorubicine (usage thérapeutique)</term><term>Femelle</term><term>Humains</term><term>Immunocompétence ()</term><term>Interféron de type I (biosynthèse)</term><term>Interféron de type I (métabolisme)</term><term>Métastase tumorale</term><term>Protéines adaptatrices du transport vésiculaire (métabolisme)</term><term>Protéines de résistance aux myxovirus (métabolisme)</term><term>Récepteur de type Toll-3 (métabolisme)</term><term>Récepteur à l'interféron alpha-bêta (métabolisme)</term><term>Récepteurs de reconnaissance de motifs moléculaires (métabolisme)</term><term>Régulation de l'expression des gènes tumoraux ()</term><term>Résultat thérapeutique</term><term>Souris de lignée C57BL</term><term>Traitement néoadjuvant</term><term>Transduction du signal ()</term><term>Tumeurs du sein (anatomopathologie)</term><term>Tumeurs du sein (génétique)</term><term>Tumeurs du sein (immunologie)</term><term>Tumeurs du sein (traitement médicamenteux)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Interferon Type I</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>RNA, Messenger</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Adaptor Proteins, Vesicular Transport</term><term>Chemokine CXCL10</term><term>Interferon Type I</term><term>Myxovirus Resistance Proteins</term><term>RNA</term><term>RNA, Messenger</term><term>Receptor, Interferon alpha-beta</term><term>Receptors, Pattern Recognition</term><term>Toll-Like Receptor 3</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anthracyclines</term><term>Doxorubicin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anthracyclines</term><term>Doxorubicin</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Interféron de type I</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Gene Expression Regulation, Neoplastic</term><term>Immunocompetence</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN messager</term><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>ARN</term><term>ARN messager</term><term>Chimiokine CXCL10</term><term>Interféron de type I</term><term>Protéines adaptatrices du transport vésiculaire</term><term>Protéines de résistance aux myxovirus</term><term>Récepteur de type Toll-3</term><term>Récepteur à l'interféron alpha-bêta</term><term>Récepteurs de reconnaissance de motifs moléculaires</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Anthracyclines</term><term>Doxorubicine</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Anthracyclines</term><term>Doxorubicine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Humans</term><term>Mice, Inbred C57BL</term><term>Neoadjuvant Therapy</term><term>Neoplasm Metastasis</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Humains</term><term>Immunocompétence</term><term>Métastase tumorale</term><term>Régulation de l'expression des gènes tumoraux</term><term>Résultat thérapeutique</term><term>Souris de lignée C57BL</term><term>Traitement néoadjuvant</term><term>Transduction du signal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Some of the anti-neoplastic effects of anthracyclines in mice originate from the induction of innate and T cell-mediated anticancer immune responses. Here we demonstrate that anthracyclines stimulate the rapid production of type I interferons (IFNs) by malignant cells after activation of the endosomal pattern recognition receptor Toll-like receptor 3 (TLR3). By binding to IFN-α and IFN-β receptors (IFNARs) on neoplastic cells, type I IFNs trigger autocrine and paracrine circuitries that result in the release of chemokine (C-X-C motif) ligand 10 (CXCL10). Tumors lacking Tlr3 or Ifnar failed to respond to chemotherapy unless type I IFN or Cxcl10, respectively, was artificially supplied. Moreover, a type I IFN-related signature predicted clinical responses to anthracycline-based chemotherapy in several independent cohorts of patients with breast carcinoma characterized by poor prognosis. Our data suggest that anthracycline-mediated immune responses mimic those induced by viral pathogens. We surmise that such 'viral mimicry' constitutes a hallmark of successful chemotherapy.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>France</li><li>Italie</li><li>Suisse</li><li>États-Unis</li></country><region><li>Auvergne (région administrative)</li><li>Auvergne-Rhône-Alpes</li><li>Bourgogne</li><li>Bourgogne-Franche-Comté</li><li>Canton de Vaud</li><li>Connecticut</li><li>District de Cologne</li><li>Languedoc-Roussillon</li><li>Latium</li><li>Lombardie</li><li>Massachusetts</li><li>Midi-Pyrénées</li><li>Missouri (État)</li><li>Occitanie (région administrative)</li><li>Rhénanie-du-Nord-Westphalie</li><li>Île-de-France</li></region><settlement><li>Bonn</li><li>Clermont-Ferrand</li><li>Dijon</li><li>Lausanne</li><li>Milan</li><li>Montpellier</li><li>Paris</li><li>Rome</li><li>Saint-Louis (Missouri)</li><li>Toulouse</li></settlement><orgName><li>Université Paris-Descartes</li><li>École de médecine (Université Washington de Saint-Louis)</li></orgName></list><tree><country name="Italie"><region name="Latium"><name sortKey="Sistigu, Antonella" sort="Sistigu, Antonella" uniqKey="Sistigu A" first="Antonella" last="Sistigu">Antonella Sistigu</name></region><name sortKey="Belardelli, Filippo" sort="Belardelli, Filippo" uniqKey="Belardelli F" first="Filippo" last="Belardelli">Filippo Belardelli</name><name sortKey="Bianchi, Marco E" sort="Bianchi, Marco E" uniqKey="Bianchi M" first="Marco E" last="Bianchi">Marco E. Bianchi</name><name sortKey="Bracci, Laura" sort="Bracci, Laura" uniqKey="Bracci L" first="Laura" last="Bracci">Laura Bracci</name><name sortKey="La Sorsa, Valentina" sort="La Sorsa, Valentina" uniqKey="La Sorsa V" first="Valentina" last="La Sorsa">Valentina La Sorsa</name><name sortKey="Proietti, Enrico" sort="Proietti, Enrico" uniqKey="Proietti E" first="Enrico" last="Proietti">Enrico Proietti</name><name sortKey="Sestili, Paola" sort="Sestili, Paola" uniqKey="Sestili P" first="Paola" last="Sestili">Paola Sestili</name><name sortKey="Urbani, Francesca" sort="Urbani, Francesca" uniqKey="Urbani F" first="Francesca" last="Urbani">Francesca Urbani</name><name sortKey="Vitale, Ilio" sort="Vitale, Ilio" uniqKey="Vitale I" first="Ilio" last="Vitale">Ilio Vitale</name><name sortKey="Ziccheddu, Giovanna" sort="Ziccheddu, Giovanna" uniqKey="Ziccheddu G" first="Giovanna" last="Ziccheddu">Giovanna Ziccheddu</name></country><country name="France"><noRegion><name sortKey="Yamazaki, Takahiro" sort="Yamazaki, Takahiro" uniqKey="Yamazaki T" first="Takahiro" last="Yamazaki">Takahiro Yamazaki</name></noRegion><name sortKey="Adam, Julien" sort="Adam, Julien" uniqKey="Adam J" first="Julien" last="Adam">Julien Adam</name><name sortKey="Andre, Fabrice" sort="Andre, Fabrice" uniqKey="Andre F" first="Fabrice" last="André">Fabrice André</name><name sortKey="Arnould, Laurent" sort="Arnould, Laurent" uniqKey="Arnould L" first="Laurent" last="Arnould">Laurent Arnould</name><name sortKey="Aymeric, Laetitia" sort="Aymeric, Laetitia" uniqKey="Aymeric L" first="Laetitia" last="Aymeric">Laetitia Aymeric</name><name sortKey="Baracco, Elisa E" sort="Baracco, Elisa E" uniqKey="Baracco E" first="Elisa E" last="Baracco">Elisa E. Baracco</name><name sortKey="Chaba, Kariman" sort="Chaba, Kariman" uniqKey="Chaba K" first="Kariman" last="Chaba">Kariman Chaba</name><name sortKey="Conforti, Rosa" sort="Conforti, Rosa" uniqKey="Conforti R" first="Rosa" last="Conforti">Rosa Conforti</name><name sortKey="Cyrta, Joanna" sort="Cyrta, Joanna" uniqKey="Cyrta J" first="Joanna" last="Cyrta">Joanna Cyrta</name><name sortKey="Delaloge, Suzette" sort="Delaloge, Suzette" uniqKey="Delaloge S" first="Suzette" last="Delaloge">Suzette Delaloge</name><name sortKey="Dessoliers, Marie Charlotte" sort="Dessoliers, Marie Charlotte" uniqKey="Dessoliers M" first="Marie-Charlotte" last="Dessoliers">Marie-Charlotte Dessoliers</name><name sortKey="Eggermont, Alexander" sort="Eggermont, Alexander" uniqKey="Eggermont A" first="Alexander" last="Eggermont">Alexander Eggermont</name><name sortKey="Enot, David P" sort="Enot, David P" uniqKey="Enot D" first="David P" last="Enot">David P. Enot</name><name sortKey="Fend, Laetitia" sort="Fend, Laetitia" uniqKey="Fend L" first="Laetitia" last="Fend">Laetitia Fend</name><name sortKey="Goubar, Aicha" sort="Goubar, Aicha" uniqKey="Goubar A" first="Aicha" last="Goubar">Aicha Goubar</name><name sortKey="Hannani, Dalil" sort="Hannani, Dalil" uniqKey="Hannani D" first="Dalil" last="Hannani">Dalil Hannani</name><name sortKey="Kepp, Oliver" sort="Kepp, Oliver" uniqKey="Kepp O" first="Oliver" last="Kepp">Oliver Kepp</name><name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name><name sortKey="Lacroix Triki, Magali" sort="Lacroix Triki, Magali" uniqKey="Lacroix Triki M" first="Magali" last="Lacroix-Triki">Magali Lacroix-Triki</name><name sortKey="Ladoire, Sylvain" sort="Ladoire, Sylvain" uniqKey="Ladoire S" first="Sylvain" last="Ladoire">Sylvain Ladoire</name><name sortKey="Ma, Yuting" sort="Ma, Yuting" uniqKey="Ma Y" first="Yuting" last="Ma">Yuting Ma</name><name sortKey="Niso Santano, Mireia" sort="Niso Santano, Mireia" uniqKey="Niso Santano M" first="Mireia" last="Niso-Santano">Mireia Niso-Santano</name><name sortKey="Penault Llorca, Frederique" sort="Penault Llorca, Frederique" uniqKey="Penault Llorca F" first="Frederique" last="Penault-Llorca">Frederique Penault-Llorca</name><name sortKey="Poirier Colame, Vichnou" sort="Poirier Colame, Vichnou" uniqKey="Poirier Colame V" first="Vichnou" last="Poirier-Colame">Vichnou Poirier-Colame</name><name sortKey="Preville, Xavier" sort="Preville, Xavier" uniqKey="Preville X" first="Xavier" last="Préville">Xavier Préville</name><name sortKey="Quidville, Virginie" sort="Quidville, Virginie" uniqKey="Quidville V" first="Virginie" last="Quidville">Virginie Quidville</name><name sortKey="Remedios, Catarina" sort="Remedios, Catarina" uniqKey="Remedios C" first="Catarina" last="Remédios">Catarina Remédios</name><name sortKey="Spano, Jean Philippe" sort="Spano, Jean Philippe" uniqKey="Spano J" first="Jean-Philippe" last="Spano">Jean-Philippe Spano</name><name sortKey="Uze, Gilles" sort="Uze, Gilles" uniqKey="Uze G" first="Gilles" last="Uzè">Gilles Uzè</name><name sortKey="Vacchelli, Erika" sort="Vacchelli, Erika" uniqKey="Vacchelli E" first="Erika" last="Vacchelli">Erika Vacchelli</name><name sortKey="Zitvogel, Laurence" sort="Zitvogel, Laurence" uniqKey="Zitvogel L" first="Laurence" last="Zitvogel">Laurence Zitvogel</name></country><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Schultze, Joachim L" sort="Schultze, Joachim L" uniqKey="Schultze J" first="Joachim L" last="Schultze">Joachim L. Schultze</name></region><name sortKey="Tuting, Thomas" sort="Tuting, Thomas" uniqKey="Tuting T" first="Thomas" last="Tüting">Thomas Tüting</name></country><country name="Suisse"><region name="Canton de Vaud"><name sortKey="Delorenzi, Mauro" sort="Delorenzi, Mauro" uniqKey="Delorenzi M" first="Mauro" last="Delorenzi">Mauro Delorenzi</name></region></country><country name="États-Unis"><region name="Connecticut"><name sortKey="Pusztai, Lajos" sort="Pusztai, Lajos" uniqKey="Pusztai L" first="Lajos" last="Pusztai">Lajos Pusztai</name></region><name sortKey="Engblom, Camilla" sort="Engblom, Camilla" uniqKey="Engblom C" first="Camilla" last="Engblom">Camilla Engblom</name><name sortKey="Pfirschke, Christina" sort="Pfirschke, Christina" uniqKey="Pfirschke C" first="Christina" last="Pfirschke">Christina Pfirschke</name><name sortKey="Pittet, Mikael" sort="Pittet, Mikael" uniqKey="Pittet M" first="Mikael" last="Pittet">Mikael Pittet</name><name sortKey="Schreiber, Robert D" sort="Schreiber, Robert D" uniqKey="Schreiber R" first="Robert D" last="Schreiber">Robert D. Schreiber</name></country><country name="Australie"><noRegion><name sortKey="Chow, Melvyn T" sort="Chow, Melvyn T" uniqKey="Chow M" first="Melvyn T" last="Chow">Melvyn T. Chow</name></noRegion><name sortKey="Smyth, Mark J" sort="Smyth, Mark J" uniqKey="Smyth M" first="Mark J" last="Smyth">Mark J. Smyth</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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